Luzi Jakob Barandun Selected Research

queuine tRNA-ribosyltransferase

1/2017	Soaking suggests "alternative facts": Only co-crystallization discloses major ligand-induced interface rearrangements of a homodimeric tRNA-binding protein indicating a novel mode-of-inhibition.
9/2013	High-affinity inhibitors of Zymomonas mobilis tRNA-guanine transglycosylase through convergent optimization.
1/2013	Launching spiking ligands into a protein-protein interface: a promising strategy to destabilize and break interface formation in a tRNA modifying enzyme.

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Luzi Jakob Barandun Research Topics

Disease

4	Bacillary Dysentery (Shigellosis) 01/2017 - 07/2012
2	Foodborne Diseases 09/2013 - 07/2012

Drug/Important Bio-Agent (IBA)

3	queuine tRNA-ribosyltransferaseIBA 01/2017 - 01/2013
1	EnzymesIBA 09/2013
1	Pharmaceutical PreparationsIBA 09/2013
1	Transfer RNA (tRNA)IBA 09/2013
1	Shiga Toxin (Shigella Toxin)IBA 07/2012

Therapy/Procedure

1	Drug Therapy (Chemotherapy) 01/2017